Endocrine Abstracts

Background: The COVID-19 pandemic has resulted in widespread disruption to delivery of emergency and elective care in the last 2 years. Nevertheless, healthcare systems have quickly readapted to accelerate use of novel pathways for delivering clinical services. We reviewed the impact of COVID-19 pandemic on our time from community referral to definitive surgery in patients with Primary Hyperparathyroidism (PHPT).Methods: We retrospectively reviewed the w...

Background: Diagnostic work-up for Cushing Syndrome (CS) can be challenging and is based on clinical and biochemical assessments. Once steroid excess is biochemically confirmed, the diagnostic serum ACTH threshold for determining ACTH-independent Cushing is debatable. A threshold of less than 15 ng/l has been adopted in our regional guidelines.Aims: To investigate serum ACTH levels in patients with proven adrenal Cushing and to assess the clinical utilit...

Background: Hypocalcaemia is a common electrolyte disorder and it can occur following parathyroidectomy or thyroidectomy. It has been suggested that some post-operative hypocalcaemic crises may reflect severe vitamin D deficiency and vitamin D supplementation may have a protective effect.Objectives: To establish the prevalence of severe post-operative hypocalcaemia (as defined by the requirement for i.v. calcium gluconate) following parathyroid surgery a...

Background: Unilateral adrenal haemorrhage is usually asymptomatic and picked up incidentally on CT imaging. However, adrenal haemorrhage can cause flank pain and when bilateral, adrenal insufficiency or adrenal crisis. Biochemical changes include electrolyte imbalances, low platelet count and anaemia. We report a case of unilateral adrenal haemorrhage with devastating outcome.Case: A 45-year-old male smoker was incident...

Phaeochromocytomas are neuroendocrine neoplasms originating from chromaffin cells of the adrenal medulla, causing 0.1–0.2% cases of hypertension. Although rare, phaeochromocytoma is potentially life-threatening, leading to hypertensive crises if unrecognised or mismanaged. Chronic thromboembolic pulmonary hypertension (CTEPH) is a potential complication of thromboembolic disease, usually resulting from ongoing vascular obstruction following pulmonary emboli. We report a c...

Section 1: Case history: A 60 year-old lady presented with a 4-year history of progressively increasing virilisation on the background of right salpingo-oophorectomy for ectopic pregnancy in 1984 (no histology available).Section 2: Investigations: Testosterone 23.6 nmol/l (NR < 1.7), LH 16 IU/l (7.7–58.5), FSH 33 IU/l (25.8–134.8), androstenedione 3.2 nmol/l (NR 1.4–14.3), DHEAs 1.2 umol/l (0.5–5.6), 17-OHP 2.7 nmol/l (1–4.5)...